Genetics
One of the most interesting chapters in biology relates to the development of the modern science of heredity, or genetics.
Previous to the year 1900, when the Mendelian principle of inheritance was re-discovered, the relative importance of heredity and of environment in the development of an organism was little understood. It is true that Weismann had insisted on the independence of soma and germplasm some years earlier (1883), but the body of the individual was still generally considered the key to its inheritance.
The recognition of the general application of Mendel’s discovery gave a great impetus to experimental breeding both in plants and animals. While heretofore it had been necessary to depend upon the somatic characters as evidence of the hereditary constitution of an individual, it now became possible, knowing the hereditary constitution of the parents of any pair of individuals, to predict with almost mathematical certainty the characters of their possible offspring.
In general, the laws of possible chance combinations of any group of characters determine the probability of any particular offspring possessing one or many of those characters. The physical basis for such Mendelian inheritance is evidently the chance combinations of chromosomes which result from the processes of maturation and union of the germ cells.
Certain limitations to the law are met with because the relatively small number of chromosomes involves linkage of genes, because of the occasional interchange of groups of genes between homologous chromosomes, and because the relative activity or potency of any particular gene may differ in different races, and, finally, because the normal activity of any given gene may be modified or inhibited by the action of other genes. It is by no means certain, however, that all inheritance is Mendelian, for there still remains much evidence that the hereditary basis of certain characters may be resident in the cytoplasm, rather than in the chromosomes. A recent book by Morgan, Sturtevant, Müller and Bridges (1915), entitled “the mechanism of Mendelian heredity” gives the cytological explanation of Mendelian inheritance.
Americans have from the first taken a leading part in this field of research and have been quick to recognize its practical applications to the improvement of breeds in both animals and plants. This prominent position is largely due to the experimental work of Castle, Davenport, Morgan, Jennings, Pearl, and their co-workers on animals and that of East, Emerson, Davis, Hayes and Shull on plants.
The geneticist now realizes that the appearance of the body (phenotype) gives but little clue to the inheritance (genotype). That two white flowers produce only purple offspring, or two white fowls only deeply colored chickens, or that a pair of guinea pigs, one of which is black and the other white, have only gray agouti offspring, while other apparently similar white flowers or white animals produce offspring like themselves, is now readily comprehensible and mathematically predictable.
The most important application of our newly acquired knowledge of inheritance is in the improvement of the human race. The wonderful opportunity in this direction must be apparent to all. The welfare of humanity depends upon the immediate adoption of eugenic principles. The Eugenics Record Office has secured many of the essential data.
With the destruction of the world’s best germ plasm at a rate never equalled before, the outlook for the future race would be appalling were it not for the hope that with the advent of a righteous peace will come a realization of the necessity of applying these new biological discoveries to improving the races of men. That the discoveries have been made too late in the world’s history to be of such use to humanity must not be thought possible.