The Monochlorurretted — Chloride of Ethyle
This substance was discovered some few years ago by M. M. G. Regnault. It is made by exposing to the sun’s rays a mixture of the vapour of chloride of ethyle (muriatic ether) and chlorine gas. One equivalent of the hydrogen of the chloride of ethyle is replaced by an equivalent of chlorine. Its composition is four atoms carbon, four atoms hydrogen, and two atoms chlorine. It has the same composition as Dutch Liquid, which is made by the combination of olefiant gas and chlorine gas; the specific gravity of its vapour, 3·42, is also the same as that of Dutch liquid, which it resembles also in taste and smell. The boiling point is however different, and it differs from Dutch liquid in not being decomposed by an alcoholic solution of potassa.
I tried several times to make the monochlorurretted chloride of ethyle in 1849 and 1850, but did not succeed in procuring more than a drachm or two at once, owing to the constant over-action of the chlorine and the production of other chlorurretted products. In 1851, however, these products which result from the decomposition of muriatic ether by chlorine gas were recommended in Paris as local applications in rheumatism and other painful affections, and Mr. Mason was kind enough to obtain for me from that capital a pint bottle of a liquid consisting chiefly of the monochlorurretted chloride of ethyle. It was mixed with a certain portion of the bichlorurretted and terchlorurretted products, but I was able to separate by distillation as much of the monochlorurretted product as enabled me to administer it to twenty-two patients. Mr. Mason was, however, not able to obtain any more liquid containing any of the monochlorurretted chloride. What he afterwards was able to obtain had a very high boiling point, and consisted chiefly of chloride of carbon; carbon four atoms, chlorine five atoms.
The monochlorurretted chloride of ethyle resembles chloroform very much in taste and smell, and in its physiological properties. Its boiling point is 149°, whilst that of chloroform is 140°; the specific gravity of its vapour is also lower; for these reasons, it is considerably less volatile than chloroform, and it is therefore pretty certain that it would not be liable to cause the sudden deaths which have occasionally been produced by the administration of chloroform, even if it were given freely and with no great care. The difficulty of procuring it in a state of purity is, however, a barrier to its introduction into practice.
I first administered this preparation in King’s College Hospital, on June 20th, 1851, to a young woman, whilst Mr. Wm. Hewett, the house surgeon, repeated the operation of paring off venereal warts and applying nitric acid. The patient breathed it very readily without appearing to suffer from the pungency. She was a little longer in becoming unconscious than on former occasions from the chloroform, but soon after becoming unconscious, the sensibility of the conjunctiva diminished, and the operation was commenced. There was some flinching, so that she required to be held, but there were no cries or other signs of sensation. Consciousness returned almost immediately, and she seemed more exhilarated than after chloroform. She had had her dinner just before the operation, and at one time, soon after recovering her consciousness, she said that she felt rather sick, but this feeling passed off without vomiting, and she did not remember it afterwards. She did not begin to cry out from the smarting till twenty minutes after the operation, when she had been quite conscious, collected, and rational for a quarter of an hour, although on the two former occasions, after chloroform had been inhaled, she began to cry immediately after the operation, and almost before consciousness had returned. Next day she was very well.
On the following day I administered the same preparation to three patients on whom Mr. Fergusson operated in King’s College Hospital. The first was a boy seven years old, who had the forefinger removed, together with part of the metacarpal bone, on account of a large enchondroma. The second was an infant three months old, which was operated on for hare-lip; and the third was a woman about thirty-five, who had some venereal warts removed from the pudenda. There was no sickness in either of the cases, although the little boy and the woman had taken their dinners just before the operation.
On June 25th, I administered the preparation with the chloroform inhaler, as in all the other cases, to a muscular young man, about 25, whilst Mr. Henry Lee removed some piles, and applied nitric acid to the raw surface. The patient was six feet three inches in height, and weighed fourteen stone. He became insensible rather slowly, with low muttering and a good deal of rigidity. The operation lasted about ten minutes, during which the inhalation was repeated two or three times. There was no pain. He recovered his consciousness in two or three minutes after the conclusion of the operation; he said that he felt drunk, and he appeared so for a few minutes. He was very cheerful, and had no sickness, although he had had his dinner just before coming to the hospital to have the operation performed. Half a fluid ounce of the monochlorurretted compound was inhaled, being about the same quantity as would have been consumed of chloroform.
The other operations in which I administered this preparation, consisted of the removal of a tumour situated below the angle of the jaw in a young woman, by Mr. Fergusson; an operation on the tibia and fibula of a little boy, for ununited fracture, by Mr. Bowman; trephining the tibia of a young man, and giving exit to a collection of pus, by Mr. Henry Lee; an operation for necrosis of the tibia, by the late Mr. Avery; two operations for hare-lip; two operations for fistula in ano; one for nævus on the forehead; one for tenotomy; and one for removal of a fatty tumour, by Mr. Fergusson.181
The End
Notes
1. Messrs. Maule and Polyblank have an excellent photographic portrait of Dr. Snow in their “Scientific Portrait Gallery” series. Mr. Empson has also a bust, which has been greatly admired for its correctness and for its superiority as an artistic work.
2. Dr. Murchison, who with Dr. Budd rendered Dr. Snow all that able assistance which the best of medicine can offer, has kindly given me several particulars in regard to the fatal illness, which I embody in the text, with many thanks.
3. Dr. Murchison has also given me an outline of the post-mortem appearances, which is subjoined. “The post-mortem examination revealed slight white softening, only detectable by the microscope, in the right corpus striatum and optic thalamus, and fatty degeneration of the minute cerebral vessels. The heart was slightly fatty, but there was no valvular disease, nor atheromatous disease of aorta. The lungs were congested, and showed marked evidence of old disease at the apices. Both the kidneys were much contracted and granular, with numerous cysts, the right organ being almost entirely converted into cysts; with the uriniferous tubes either denuded, or containing granular disintegrating epithelium. There was distinct cicatrix of an old ulcer in duodenum, and the stomach was much congested, with numerous hæmorrhagic spots.”
4. See Monthly Journal of Med. Sc., vol. viii, p. 452.
5. Liber iv, cap. 76.?
6. Loc. cit.
7. Natural. Hist., lib. xxv, cap. 13.
8. De Herbarum Virtutibus, cap. 131.
9. Medical Botany, p. 236.
10. De Causis Morb. Diut., lib. i, cap. 6.
11. De Morbis Acutis, lib. i, cap. 4.
12. Vet. Acad. Handl., 1763, vol. xxiv, p. 229.
13. Comptes Rendus de l’Acad. de Sc., t. xxviii, 1849, p. 195.
14. See Herodotus, book iv, 73–5.
15. Lib. iv, cap. 8.
16. Med. Gaz., vol. xli, p. 515.
17. Observations sur la Physique, tome xvi (1780), p. 256.
18. Method of preventing or diminishing Pain in several Operations of Surgery. Lond. 1784.
19. Gazette des Hôpitaux, 1st April, 1854.
20. Hypnotism is the term employed by Mr. Braid of Manchester for the peculiar sleep produced by the Mesmerists.
21. Record of Cases treated in the Mesmeric Hospital. Calcutta, 1848.
22. Cary’s Herodotus, book i, 202.
23. Book iv, 73–5.
24. Liber viii, cap. 1.
25. Translated into Latin by Father Angelus, Paris, 1681, p. 21.
26. P. 287.
27. P. 88.
28. See Medicinal Use of Different Kinds of Airs, by Dr. Pearson. Birmingham, 1795.
29. Researches concerning Nitrous Oxide, p. 556.
30. See 32nd Congress, 2nd Session [Senate] Rep. Com. No. 421, p. 17.
31. Vol. iv, p. 158.
32. A Defence of Dr. Charles T. Jackson’s Claims to the Discovery of Etherization. Boston, 1848.
33. The Inhalation of the Vapour of Ether in Surgical Operations. By John Snow, M.D. 1847.
34. Pharmaceutical Journal, Feb. 1847, p. 357; and Med. Gaz., 1847, vol. xl, p. 939.
35. Quoted in Med. Gaz., 1847, vol. xl, p. 1153.
36. Lancet, Nov. 27, 1847, p. 575; and Med. Gaz., 1847, vol. xl, p. 1031.
37. Dr. Pereira in Pharmaceutical Journal, March 1846, vol. v, No. 9.
38. Silliman’s American Journal of Science and Art, vol. xxi, p. 64, Jan. 1832.
39. Ann. de Chim. et de Physique, t. xlviii, p. 131.
40. Ibid., t. xlix, p. 146.
41. Ibid., t. lvi, p. 134.
42. Formic acid is so named because it was originally obtained from the red ant (Formica rufa). It is now made from starch.
43. Turner’s Chemistry, 8th ed., p. 1009.
44. Nearly all the chloroform used in Great Britain and her colonies is made in Edinburgh, where the spirit duty is lower than in England. The London druggists have almost ceased to make it, as they find it cheaper to get it from the trade in Edinburgh.
45. The Edinburgh druggists suffered a great loss in 1850 from purifying their chloroform in this way on the recommendation of Dr. Gregory, who was not aware of the consequences, although they had been stated by Dumas (Ann. de Chim. et de Physique, t. lvi, p. 117).
46. I have seen some specimens of chloroform that left a white, limy-looking stain on the hand, which I believe was a minute quantity of crystalline chloride of carbon. These specimens were unobjectionable for all practical purposes, and had the merit of keeping remarkably well.
47. See Med. Gaz., vol. xl, p. 1092.
48. Dr. Letheby in Med. Gaz., vol. xlvi, p. 1037.
49. Lancet, Feb. 12, 1848.
50. Since the above was written, I have met with an instance in which the pulse was only 40 in the minute, as the effects of the chloroform were subsiding. There was neither sickness nor loss of blood. The case was that of a gentleman in good general health, who inhaled chloroform whilst Mr. Brodhurst endeavoured to make forcible flexion of the femur on the pelvis. He woke without any unpleasant symptoms, and the pulse resumed its natural frequency.
51. Gazette des Hôpitaux, 20 Mars, 1847.
52. Medical Gazette, vol. xli-ii.
53. According to Professor Miller, chloroform was given, at one time, in the Royal Infirmary of Edinburgh, in a somewhat slovenly, and not very cleanly manner; he describes the means of applying it as, “anything that will admit of chloroform in vapour being brought fully in contact with the mouth and nostrils; a handkerchief, a towel, a piece of lint, a worsted glove, a nightcap, a sponge.” He says, “In the winter season, the glove of a clerk, dresser, or onlooker, has been not unfrequently pressed into the service.... The object is to produce insensibility as completely and as soon as we can; and there is no saying, à priori, whether this is to be accomplished by fifty drops or five hundred. We begin with generally two or three drachms spilt on the handkerchief or lint; and we refresh that, or not, from time to time, as circumstances require.” Surgical Experience of Chloroform, Edin., 1848, pp. 16 and 17. The italics are not in the original.
54. Curious arguments are sometimes used in support of the idea of peculiarities and idiosyncrasies. A medical man informed me, one day, that he had seen a patient inhale an ounce of chloroform without any effect. I expressed my opinion that if she had taken the vapour of one drachm into her lungs within four minutes, or the vapour of a little more than half a drachm within two minutes, she would have been insensible; and that the chloroform had mostly evaporated into the room, without entering the patient’s lungs. Then, he said, it would have made all of us insensible. Now to charge the air of a moderate sized room of twenty feet square and ten feet high, uniformly with only a grain and a half of chloroform to each hundred cubic inches, so that, if all the crevices were closed, a person inside might, in course of time, absorb about eighteen minims of the medicine, and be rendered insensible, would require nearly fifteen pounds of chloroform.
55. The increase of effects of chloroform after the inhalation is discontinued, was pointed out by Prof. Sédillot of Strasbourg and myself almost simultaneously. I explained the circumstance in a paper read to the Westminster Medical Society, on January 8th, 1848, and M. Sédillot announced it to the Academy of Sciences of Paris, on January 10th. My remarks were published in the Medical Gazette of January 14th, and those of M. Sédillot in the Gazette Médicale of January 15th.
56. I have reason to conclude that the increased secretion of saliva is caused, not so much by the action of the chloroform on the mucous membrane of the mouth, and the extremities of the gland ducts, as by its action on the capillary circulation of the glands themselves; for on inhaling the vapour carefully by the nostrils, so that none enters the mouth, I still find that there is an increased secretion of saliva.
57. London Journal of Medicine, April 1852.
In one of the latest communications of Dr. Marshall Hall to the Lancet, he did me the honour to quote the account of the three following experiments, together with some accompanying remarks from the London Journal of Medicine, and to make the following observation respecting the pages from which he quoted.
“I have no hesitation in affirming that the first three pages of this paper are amongst the most able and valuable in physiology, and I beg to be allowed to reproduce them in the pages of the Lancet.” (Lancet, April 18th, 1857, p. 397.)
58. Edin. Med. and Surg. Journal, vol. lviii.
59. Lond. Med. Gaz., vol. xlii, p. 414.
60. London Journal of Medicine, April, 1852.
61. London Medical Gazette, vol. xlii, 1848, p. 109.
62. On the Inhalation of the Vapour of Ether, p. 82.
63. Medical Gazette, vol. xlii, p. 415.
64. See l’Union Médicale, 1855, No. 13.
65. London Medical Gazette, vol. xli, p. 255.
66. Opus cit., p. 253.
67. Opus cit., p. 341.
68. London Medical Gazette, vol. xli, p. 75.
69. London Medical Gazette, vol. xlii, p. 80, from Western Lancet, and Phil. Med. Exam. April 1848.
70. Vol. xliii, p. 682.
71. Gazette Médicale, 8 Juillet, 1848; and London Medical Gazette, vol. xlii, p. 211.
72. Proceedings of Academy on Feb. 6th, 1849. See London Journal of Med., 1849, p. 307.
73. London Journal of Medicine, 1849, p. 324.
74. Lond. Med. Gaz., vol. xliii, p. 694.
75. London Med. Gaz., vol. xlii, p. 84.
76. Bouisson, Traité de la Méthode Anesthésique, p. 398.
77. London Med. Gaz., vol. xliii, p. 41.
78. Ibid., p. 712.
79. Ibid., p. 747, from l’Union Médicale.
80. Lancet, 1849, vol. i, p. 205.
81. L’Union Médicale, Sept. 8th, 1849; and Med. Gaz., vol. xliv, p. 478.
82. Lond. Med. Gaz., vol. xliv, p. 757.
83. Journal of Prov. Med. and Surg. Assoc., 1849, p. 698.
84. Casper’s Wochenschrift, Jan. 12, 1850; and Lond. Med. Gaz., vol. xlv, p. 483.
85. Edin. Monthly Journal, April 1850, p. 377.
86. Hygiea, October 1850, p. 602.
87. Lond. Med. Gaz., vol. xlvi, p. 39.
88. Lancet, 1850, vol. ii, p. 21.
89. L’Union Médicale, January 29, 1852.
90. Medical Times, 1851, vol. ii, p. 98.
91. Medical Times, 1851, vol. ii, p. 620.
92. Medical Times and Gazette, vol. i, p. 293.
93. Medical Times and Gazette, p. 318.
94. See a clinical lecture by Mr. Stanley, Med. Times, Nov. 22, 1851.
95. Gaz. Médicale, 1852, p. 630, from Medicinisches Correspondenz Blatt.
96. Medical Times and Gazette, 1852, vol. ii, p. 531.
97. Monthly Journal of Med., vol. xv, 1852, p. 377.
98. Lancet, 1853, vol. i, p. 21.
99. Lancet, 1853, vol. i, p. 307.
100. Med. Times and Gaz., 1853, vol. ii, p. 47.
101. Monthly Journal, Nov. 1853, p. 427.
102. Since writing the above, I have noted by the watch the time which a surgeon occupied in shaving the perinæum before the operation of lithotomy; it was twelve seconds.
103. Medical Times and Gazette, 1853, vol. ii, p. 422.
104. Medical Times and Gaz., 1853, vol. ii, p. 449.
105. Ibid., p. 450.
106. Edin. Monthly Jour., vol. xix, 1854, p. 372.
107. Med. Times and Gaz., 1854, vol. i, p. 19, from Med. Zeitung von den Vercine für Heilkunde in Preussen, No. 44, Berlin, Nov. 2, 1853.
108. Association Med. Jour., 1854, p. 109.
109. L’Union Médicale, 1854, p. 171.
110. Ibid., p. 187.
111. Association Medical Journal, 1854, p. 315.
112. Medical Times, 1854, vol. i, p. 572.
113. Medical Times and Gazette, 1854, vol. ii, p. 86.
114. Med. Times and Gaz., 1854, vol. ii, p. 390.
115. Ibid., p. 442.
116. Med. Times and Gaz., 1854, vol. ii, p. 501.
117. Medical Times and Gazette, 1855, vol. i, p. 363.
118. Edin. Med. Jour., 1855, p. 524.
119. 1855, vol. ii, p. 479.
120. Medical Times and Gazette, 1856, vol. ii, p. 442.
121. Association Med. Jour., 1856, p. 903.
122. Medical Times and Gaz., 1856, vol. i, p. 236.
123. Lancet, 1857, vol. i, p. 429.
124. Med. Times and Gaz., 1857, vol. ii, p. 171.
125. Med. Times and Gaz., 1852, vol. i, p. 627.
126. Gaz. Médicale, 1853, p. 304.
127. Lancet, 1848, vol. ii, p. 47.
128. Bouisson, Méthode Anesthésique, p. 398.
129. Casper’s Wochenschrift, September 6, 1850; and London Med. Gaz. vol. xlvii, p. 261.
130. Medical Times and Gazette, 1854, vol. i, p. 516.
131. Ibid., p. 517.
132. Chloroform: How shall we ensure Safety in its Administration? Pamphlet. London: 1855.
133. See some interesting papers on the value of recumbent position in syncope, by Dr. Richardson, in the Association Medical Journal for 1854. I entirely agree with Dr. Richardson that no kind of syncope commences at the brain, and that, during recovery, the heart always resumes its functions before consciousness is restored. The restoration of the heart’s action in ordinary syncope by the re-supply of blood to its cavities, without any alteration in the condition of the brain, was well proved by Dr. Richardson by means of some interesting experiments on animals which I had the opportunity of witnessing.
134. Oration before the Hunterian Society. Pamphlet, 1855.
135. Hydrochloric acid gas and ammonia are no exceptions to this rule, for they cease to exist as gases so soon as they come in contact with the moist lining membrane of the air-passages. Carbonic acid gas will be treated of in another part of this work.
136. See Med. Times and Gaz., 1853, vol. ii, p. 562.
137. See above, p. 75.
138. Edin. Monthly Jour., 1853, vol. xvii, p. 220.
139. Med. Times and Gaz., 1852, vol. i, p. 627.
140. L’Union Médicale, 1850, p. 411.
141. Lond. Med. Gaz., vol. xliii, p. 230.
142. Medical Times and Gaz., 1856, vol. ii, p. 413.
143. Med. Times and Gaz., 1856, vol. ii, p. 478.
144. Ib., 1857, vol. i, p. 559.
145. Page 648.
146. Practical Surgery, 3rd ed., p. 682.
147. I never allow of a cork or any such substance being put into a patient’s mouth when insensible unless it is well tied to a string, lest it should be swallowed.
148. Fourth edit., vol. ii, p. 467.
149. It was made by Mr. Matthews, Portugal Street. It was not contrived by me.
150. London Journal of Medicine, vol. i, pp. 54, 976.
151. See Medical Times and Gaz., 1855, vol. i, p. 361.
152. Dr. Watson defends the original name of this complaint, delirium tremens. He says:—“But they who object to delirium tremens appear to see no harm in delirium ferox: whereas it is just as incorrect to say delirium is fierce, as to say that it trembles: it is the patient who is furious, even as it is the patient who trembles.” Now, in speaking of a patient, we may speak either of his mind or his body: we may say that a person is learned, or that he is fat. A patient may be fierce on account of the kind of delirium with which his mind is affected, and the term ferox applies both to him and the complaint; but the act of trembling affects only his body.
153. Med. Gaz., vol. xli, 1848, p. 102.
154. Association Med. Jour., 1853, p. 706.
155. See Med. Times and Gaz., 1853, vol. ii, p. 412.
156. Med. Times and Gaz., 1857, vol. ii, p. 553, and 600.
157. Med. Times and Gaz., 1856, vol. ii, p. 528.
158. Brande’s Chemistry, 5th ed., p. 1274.
159. Lond. Med. Gaz., Feb. 1842.
160. On the Inhalation of the Vapour of Ether in Surgical Operations. London, 1847.
161. Papers on Narcotism by Inhalation. Lond. Med. Gaz., vol. xli-ii.
162. Lancet, Jan. 1, 1848.
163. Vol. xxxix, p. 271.
164. Medical Gazette, vol. xxxix, p. 358.
165. Gaz. Médicale, Mars 4, 1848, p. 170.
166. Gaz. des Hôpitaux, Juin 18, 1853.
167. Medical Gazette, vol. xxxix, p. 414.
168. Ibid., vol. xxxix, p. 585.
169. Medical Gazette, vol. xxxix, p. 631.
170. Méthode Anesthésique, p. 394.
171. American Journal of Med. Science, July 1857, p. 284.
172. Annales de Chimie et de Physique, 3ème série, tom. xii, p. 320.
173. 15, Hanover Street, Hanover Square.
174. Bulletin Général de Thérapeutique, t. lii, p. 312.
175. L’Union Médicale, p. 175.
176. Less than an ounce of amylene was poured out, and it was not all used.
177. Medical Times and Gazette, 1857, vol. i, p. 84.
178. British Medical Journal, March 28th, 1857.
179. Bulletin Général de Thérapeutique, t. lii, p. 223.
180. Gazette Hebdomadaire, 1857, p. 164.
181. In the act of writing this last sentence, Dr. Snow was seized with his fatal illness. The sentence required, however, but the addition of a word or two, to render it complete.—[Editor.]
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| ANATOMY. | |
| PAGE | |
|---|---|
| Anatomical Remembrancer | 1003 |
| Beale on Liver | 1005 |
| Hassall’s Micros. Anatomy | 1014 |
| Holden’s Human Osteology | 1015 |
| Jones’ and Sieveking’s Pathological Anatomy | 1017 |
| Maclise’s Surgical Anatomy | 1019 |
| Paget’s Catalogue | 1021 |
| Sibson’s Medical Anatomy | 1025 |
| Toynbee’s Catalogue | 1028 |
| Wheeler’s Handbook | 1030 |
| Wilson’s Anatomy | 1031 |
| CHEMISTRY. | |
| Abel & Bloxam’s Handbook | 1004 |
| Bowman’s Practical Chemistry | 1007 |
| Do. Medical do. | 1007 |
| Chalmers’ Electro-Chemistry | 1008 |
| Fownes’ Manual of Chemistry | 1012 |
| Do. Actonian Prize | 1012 |
| Do. Qualitative Analysis | 1012 |
| Do. Chemical Tables | 1012 |
| Fresenius’ Chemical Analysis | 1012 |
| Galloway’s First Step | 1012 |
| Do. Analysis | 1012 |
| Do. Diagrams | 1012 |
| Griffiths’ Four Seasons | 1013 |
| Horsley’s Chem. Philosophy | 1016 |
| Jones.—Mulder on Wine | 1017 |
| Odling’s Practical Chemistry | 1021 |
| Plattner on Blowpipe | 1022 |
| Speer’s Pathol. Chemistry | 1026 |
| CHOLERA. | |
| Acland on Cholera at Oxford | 1003 |
| Baly and Gull—Reports | 1004 |
| Snow on Cholera | 1026 |
| CLIMATE. | |
| Francis on Change of Climate | 1012 |
| Hall on Torquay | 1014 |
| Haviland on Climate | 1014 |
| Lee on Climate | 1018 |
| Martin on the Undercliff | 1019 |
| Martin (J. R.) on Tropical | 1020 |
| DEFORMITIES, &c. | |
| Bigg on Deformities | 1006 |
| Bishop on Deformities | 1006 |
| Do. Articulate Sounds | 1006 |
| Brodhurst on Spine | 1007 |
| Do. on Clubfoot | 1007 |
| Hare on Spine | 1014 |
| Hugman on Hip-Joint | 1016 |
| Inman on Spine | 1016 |
| Tamplin on Spine | 1027 |
| DENTISTRY. | |
| Blundell’s Painless Extraction | 1007 |
| Clark’s Odontalgist | 1009 |
| Gray on the Teeth | 1013 |
| Odontological Soc. Transactions | 1021 |
| DISEASES of the URINARY and GENERATIVE ORGANS, and SYPHILIS. | |
| Acton on Reproductive Organs | 1003 |
| Coote on Syphilis | 1009 |
| Coulson on Bladder | 1010 |
| Do. on Lithotomy | 1010 |
| Egan on Syphilis | 1011 |
| Judd on Syphilis | 1017 |
| Milton on Gonorrhœa | 1020 |
| Parker on Syphilis | 1022 |
| Todd on Urinary Organs | 1028 |
| Wilson on Syphilis | 1031 |
| DISEASES OF WOMEN AND CHILDREN. | |
| Bennet on Uterus | 1005 |
| Do. on Uterine Pathology | 1005 |
| Bird on Children | 1006 |
| Brown on Women | 1007 |
| Do. on Scarlatina | 1007 |
| Eyre’s Practical Remarks | 1011 |
| Hood on Crowing | 1016 |
| Lee’s Ovarian & Uterine Diseases | 1018 |
| Lee on Diseases of Uterus | 1018 |
| Do. on Speculum | 1018 |
| Roberton on Women | 1024 |
| Rowe on Females | 1024 |
| Smith on Leucorrhœa | 1025 |
| Tilt on Diseases of Women | 1027 |
| Do. on Change of Life | 1027 |
| Underwood on Children | 1028 |
| West on Women | 1029 |
| Whitehead on Abortion | 1030 |
| HYGIENE. | |
| Armstrong on Naval Hygiene | 1003 |
| Beale’s Laws of Health | 1004 |
| Do. Health and Diseases | 1004 |
| Blundell’s Medicina Mechanica | 1006 |
| Carter on Training | 1008 |
| Cornaro on Long Life | 1009 |
| Hartwig on Sea Bathing | 1014 |
| Do. Physical Education | 1014 |
| Hufeland’s Art | 1016 |
| Lee’s Watering Places of England | 1018 |
| Do. do. Germany, France, and Switzerland | 1018 |
| Lee’s Rhenish Watering Places | 1018 |
| Pickford on Hygiene | 1022 |
| Robertson on Diet | 1024 |
| Roth on Movements | 1024 |
| Rumsey’s State Medicine | 1024 |
| Van Oven’s Decline of Life | 1029 |
| Wilson on Healthy Skin | 1031 |
| Do. on Mineral Waters | 1031 |
| MATERIA MEDICA and PHARMACY. | |
| Bateman’s Magnacopia | 1004 |
| Beasley’s Formulary | 1005 |
| Do. Receipt-Book | 1005 |
| Do. Book of Prescriptions | 1005 |
| Lane’s Materia Medica | 1017 |
| Pereira’s Selecta e Præscriptis | 1022 |
| Pharmacopœia Londinensis | 1022 |
| Prescriber’s Pharmacopœia | 1023 |
| Royle’s Materia-Medica | 1024 |
| Spurgin’s Materia Medica | 1026 |
| Squire’s Pharmacopœia | 1026 |
| Steggall’s Materia Medica | 1026 |
| Do. First Lines for Chemists | 1026 |
| Stowe’s Toxicological Chart | 1027 |
| Taylor on Poisons | 1027 |
| Wittstein’s Pharmacy | 1031 |
| MEDICINE. | |
| Adams on Rheumatic Gout | 1004 |
| Addison on Supra-Renal Capsules | 1004 |
| Addison on Cells | 1003 |
| Alexander on Rheumatism | 1003 |
| Arnott on a Local Anæsthenic | 1003 |
| Barclay on Diagnosis | 1005 |
| Barlow’s Practice of Medicine | 1004 |
| Beale on Urine | 1005 |
| Billing’s First Principles | 1005 |
| Bird’s Urinary Deposits | 1006 |
| Bird on Charcoal | 1006 |
| Brinton on Ulcer | 1007 |
| Budd on the Liver | 1007 |
| Do. on Stomach | 1007 |
| Camplin on Diabetes | 1008 |
| Chambers on Digestion | 1008 |
| Davey’s Ganglionic | 1010 |
| Eyre on Stomach | 1011 |
| Fuller on Rheumatism | 1012 |
| Gairdner on Gout | 1012 |
| Garrett on E. and N. E. Winds | 1012 |
| Granville on Sudden Death | 1013 |
| Gully’s Simple Treatment | 1013 |
| Habershon on Stomach | 1013 |
| Hall on Apnœa | 1014 |
| Hall’s Observations | 1014 |
| Harrison on Lead in Water | 1014 |
| Headland on Medicines | 1015 |
| Hooper’s Medical Dictionary | 1016 |
| Hooper’s Physician’s Vademecum | 1013 |
| Jones’ Animal Chemistry | 1017 |
| Lugol on Scrofula | 1019 |
| Peacock on Influenza | 1022 |
| Do. on Heart | 1022 |
| Pym on Yellow Fever | 1023 |
| Roberts on Palsy | 1024 |
| Robertson on Gout | 1024 |
| Savory’s Compendium | 1024 |
| Semple on Cough | 1025 |
| Shaw’s Remembrancer | 1025 |
| Steggall’s Medical Manual | 1026 |
| Do. Gregory’s Conspectus | 1026 |
| Do. Celsus | 1026 |
| Thomas’ Practice of Physic | 1027 |
| Wegg’s Observations | 1029 |
| Wells on Gout | 1030 |
| What to Observe | 1019 |
| Whitehead on Transmission | 1030 |
| Williams’ Principles | 1030 |
| Wright on Headaches | 1030 |
| MICROSCOPE. | |
| Beale on Microscope in Medicine | 1005 |
| Do. How to Work | 1005 |
| Carpenter on Microscope | 1008 |
| Schacht on do. | 1025 |
| MISCELLANEOUS. | |
| Acton on Prostitution | 1003 |
| Atkinson’s Bibliography | 1004 |
| Bascome on Epidemics | 1005 |
| Bryce on Sebastopol | 1008 |
| Cooley’s Cyclopædia | 1009 |
| Forbes’ Nature and Art in Disease | 1011 |
| Gully on Water Cure | 1013 |
| Guy’s Hospital Reports | 1013 |
| Haycock’s Veterinary | 1015 |
| Lane’s Hydropathy | 1018 |
| Marcet on Food | 1019 |
| Massy on Recruits | 1020 |
| Oxford Editions | 1021 |
| Part’s Case Book | 1022 |
| Pettigrew on Superstitions | 1022 |
| NERVOUS DISEASES AND INDIGESTION. | |
| Anderson on Nervous Affections | 1004 |
| Arnott on Indigestion | 1003 |
| Carter on Hysteria | 1008 |
| Child on Indigestion | 1008 |
| Downing on Neuralgia | 1011 |
| Hunt on Heartburn | 1016 |
| Lobb on Nervous Affections | 1019 |
| Radcliffe on Epilepsy | 1023 |
| Reynolds on the Brain | 1023 |
| Rowe on Nervous Diseases | 1024 |
| Sieveking on Epilepsy | 1025 |
| Todd on Nervous System | 1028 |
| Turnbull on Stomach | 1028 |
| OBSTETRICS. | |
| Barnes on Placenta Prævia | 1004 |
| Lee’s Clinical Midwifery | 1018 |
| Pretty’s Aids during Labour | 1023 |
| Ramsbotham’s Obstetrics | 1023 |
| Do. Midwifery | 1023 |
| Smellie’s Obstetric Plates | 1025 |
| Smith’s Manual of Obstetrics | 1025 |
| Do. Periodoscope | 1025 |
| Swayne’s Aphorisms | 1026 |
| Waller’s Midwifery | 1029 |
| OPHTHALMOLOGY. | |
| Cooper on Near Sight | 1009 |
| Dalrymple on Eye | 1010 |
| Dixon on the Eye | 1011 |
| Hogg on Ophthalmoscope | 1015 |
| Holthouse on Strabismus | 1015 |
| Do. on Impaired Vision | 1015 |
| Jacob on Eye-ball | 1016 |
| Jones’ Ophthalmic Medicine | 1017 |
| Do. Defects of Sight | 1017 |
| Do. Eye and Ear | 1017 |
| Walton on Ophthalmic | 1029 |
| PHYSIOLOGY. | |
| Carpenter’s Human | 1008 |
| Do. Comparative | 1008 |
| Do. Manual | 1008 |
| Cottle’s Human | 1010 |
| Hilton on the Cranium | 1015 |
| Richardson on Coagulation | 1023 |
| PSYCHOLOGY. | |
| Bucknill and Tuke’s Psychological Medicine | 1007 |
| Burgess on Madness | 1007 |
| Burnett on Insanity | 1009 |
| Conolly on Asylums | 1009 |
| Davey on Nature of Insanity | 1010 |
| Dunn’s Physiological Psychology | 1011 |
| Hood on Criminal Lunatics | 1016 |
| Jacobi on Hospitals, by Tuke | 1028 |
| Knaggs on Criminal Lunatics | 1017 |
| Millingen on Treatment of Insane | 1020 |
| Monro on Insanity | 1020 |
| Do. Private Asylums | 1020 |
| Noble on Psychology | 1020 |
| Do. on Mind | 1020 |
| Williams (J.) on Insanity | 1030 |
| Williams (J. H.) Unsoundness of Mind | 1030 |
| Winslow’s Lettsomian | 1031 |
| Do. Law of Lunacy | 1031 |
| PULMONARY and CHEST DISEASES, &c. | |
| Addison on Healthy and Diseased Structure | 1003 |
| Billing on Lungs and Heart | 1005 |
| Blakiston on the Chest | 1006 |
| Bright on the Chest | 1007 |
| Cotton on Consumption | 1010 |
| Do. on Stethoscope | 1010 |
| Davies on Lungs and Heart | 1011 |
| Fenwick on Consumption | 1011 |
| Laennec on Auscultation | 1017 |
| Madden on Consumption | 1019 |
| Markham on Heart | 1020 |
| Richardson on Consumption | 1023 |
| Skoda on Auscultation | 1019 |
| Thompson on Consumption | 1027 |
| Wardrop on the Heart | 1029 |
| Weber on Auscultation | 1029 |
| SCIENCE. | |
| Bird’s Natural Philosophy | 1006 |
| Burnett’s Philosophy of Spirits | 1008 |
| Garner’s Eutherapeia | 1013 |
| Hardwich’s Photography | 1014 |
| Hinds’ Harmonies | 1015 |
| Holland on Appendages | 1015 |
| Jago on Ocular Spectres | 1016 |
| Jones on Vision | 1017 |
| Do. on Body, Sense, and Mind | 1017 |
| Mayne’s Lexicon | 1019 |
| Price’s Photographic Manipulation | 1023 |
| Nourse’s Students’ Tables | 1021 |
| Reymond’s Animal Electricity | 1023 |
| Taylor’s Medical Jurisprudence | 1027 |
| Vestiges of Creation | 1028 |
| Sequel to ditto | 1028 |
| Unger’s Botanical Letters | 1028 |
| SURGERY. | |
| Arnott on Urethra | 1003 |
| Ashton on Rectum | 1004 |
| Bellingham on Aneurism | 1006 |
| Bigg on Artificial Limbs | 1006 |
| Bishop on Bones | 1006 |
| Chapman on Ulcers | 1009 |
| Do. Varicose Veins | 1009 |
| Cooper (Sir A.) on Testis | 1010 |
| Cooper’s (B.) Surgery | 1009 |
| Do. (S.) Surg. Dictionary | 1009 |
| Curling on Rectum | 1010 |
| Do. on Testis | 1010 |
| Druitt’s Surgery | 1011 |
| Fergusson’s Surgery | 1011 |
| Gay on Femoral Rupture | 1013 |
| Do. on Ulcers | 1013 |
| Harrison on Stricture | 1014 |
| Higginbottom on Nitrate of Silver | 1015 |
| Hodgson on Prostate | 1015 |
| Hunt on Skin | 1016 |
| Laurence on Cancer | 1018 |
| Lawrence on Ruptures | 1018 |
| Lee on Hæmorrhoids | 1018 |
| Liston’s Surgery | 1018 |
| Macleod’s Surgery of the Crimea | 1019 |
| Maclise on Fractures | 1019 |
| Nottingham on the Ear | 1020 |
| Nunneley on Erysipelas | 1021 |
| Pirrie on Surgery | 1022 |
| Skey’s Operative Surgery | 1025 |
| Smith on Stricture | 1025 |
| Steggall’s Surgical Manual | 1026 |
| Thompson on Stricture | 1027 |
| Wade on Stricture | 1029 |
| Watson on the Larynx | 1029 |
| Wilson on the Skin | 1031 |
| Do. Portraits of Skin Diseases | 1031 |
| Yearsley on Deafness | 1031 |
| Do. on Throat | 1031 |
DR. ACLAND.
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